Dmm023606 1341..1343
نویسنده
چکیده
The International Mouse Phenotyping Consortium (IMPC) is a major international effort to explore the effects of knocking out 20,000 genes in the mouse. A new study by White and colleagues, published in the current issue of Disease Models & Mechanisms, demonstrates the usefulness of lacZ in situ reporter expression patterns in extending our understanding of genotype-phenotype relationships as part of the IMPC high-throughput screen. In situ gene expression profiling is invaluable for evaluating compartment-specific gene expression patterns, and these enrich our understanding of the role of genes in a great number of biological processes in multiple organ systems. Furthermore, the complexity of gene expression patterns informs our understanding of how genes influence lethality. This Editorial aims to highlight ways in which the lacZ expression profiles can impact on biomedical research by uncovering as-yet-unknown genotypephenotype relationships, and through predicting the role of genes in
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Part 1980—procedures for the Handling of Discrimination Complaints under Section 806 of the Corporate and Criminal Fraud Account- Ability Act of 2002, Title Viii of the Sarbanes-oxley Act
(a) This part implements procedures under section 806 of the Corporate and Criminal Fraud Accountability Act of 2002, Title VIII of the Sarbanes-Oxley Act of 2002 (‘‘Sarbanes-Oxley’’ or ‘‘Act’’), enacted into law July 30, 2002. Sarbanes-Oxley provides for employee protection from discrimination by companies and representatives of companies because the employee has engaged in protected activity ...
متن کاملThe effect of thiamylal and propanidid on the isolated heart muscle in comparison with CT 1341.
IWATSUKI, N. The Effect of Thiamylal and Propanidid on the Isolated Heart Muscle in Comparison with CT 1341. Tohoku J. exp. Med ., 1973, 110 (1), 3340 Inotropic effects of thiamylal and propanidid on the contractile state of the isolated dog heart muscle were determined by means of force-velocity relations and compared with those of CT 1341, a new steroid anesthetic. All anesthetics studied pro...
متن کاملThe effect of CT 1341, a new steroid anesthetic, on the isolated heart muscle.
IWATSUKI, N. The Effect of CT 1341, a New Steroid Anesthetic, on the Isolated Heart Muscle. Tohoku J. exp. Med., 1973, 109 (1), 69-75 A direct inotropic effect of CT 1341, a new steroid intravenous anesthetic, upon the myocardium was studied in isolated heart muscles of dogs by measurements of force-velocity relation. CT 1341 at the concentrations over 0.139 ml/100 ml caused a dose-dependent le...
متن کاملClin Pharmacokinet 2003; 42 (15): 1331-1357
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1331 1. Nuclear Receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1332 1.1 Orphan Receptors . . . . . . . . . . . . . . . . . . . . ....
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